Phenergan Vs Ondansetron Dose

The recommended dose of ondansetron for PONV prophylaxis is 4 mg5,6,17,21. Triple combination regiments are recommended for patients at high risk for PONV and CINV. We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dose of metoclopramide, promethazine or normal. Kothari SN(1), Boyd WC, Bottcher ML, Lambert PJ. Since the first clinical trials of the antiemetic efficacy of ondansetron to prevent postoperative nausea and vomiting (PONV) were published in 1991, the manufacturer has run an extensive clinical research program to establish the optimal dose and route of administration.1,2. 4 mg ondansetron demonstrated complete resolution of PONV ( 78.2% vs. A pairwise analysis similarly demonstrated a significant prolongation of the QT interval at 6, 12, and 14 minutes. I was given a dose of Zofran and a motion sickness patch before surgery to try and prevent this as I get nauseous from pain meds so easilythat didn’t work Zofran (ondansetron) works well to prevent nausea and vomiting. Promethazine is available in 12.5, 25 and 50 mg tablet form, 6.25 mg/5 ml syrup and 25 mg suppositories. Promethazine (Phenergan) is similar in efficacy to ondansetron (Zofran), and oral methylprednisolone (Medrol) is more effective than promethazine in the treatment of patients with hyperemesis. Solution for injection is manufactured in concentrations of 25 mg/ml and 50 mg/ml, each in. Consider 6.25 to 12.5 mg of promethazine as the starting IV dose, especially for elderly patients. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. Ondansetron (Zofran) 8 mg orally two or three times. Chemotherapy drugs increase production of serotonin that stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Just like many other medications, ondansetron can prolong the QTc interval on an electrocardiogram. The dose of ondansetron doses (100–150 µg/kg) may be reduced when used in combination with another antiemetic (Tramer 2001). Phenergan (Promethazine HCl) Suppositories, USP are for rectal administration only. Author information: (1)Department of Surgery, Gundersen Lutheran, 1836 South Avenue, La Crosse, WI 54601, USA The dose of ondansetron doses (100–150 µg/kg) may be reduced when used in combination with another antiemetic (Tramer 2001). Zofran costs more while Phenergan is cheap In the PACU (), the complete response rate was 68% after rescue with promethazine and 50% after rescue with a repeat dose of ondansetron (P < 0.0001).There was no difference between the two groups in the amount of opioid boluses given for the control of acute pain or in the duration of PACU stay The ondansetron-treated group showed a greater need for re-administration of the medication (50.6% vs. Zofran (ondansetron) and Compazine (prochlorperazine) are prescribed for the treatment of nausea and vomiting Zofran is often used to prevent and treat nausea and vomiting during chemotherapy and after surgery Compazine is also used to treat psychotic disorders such as schizophrenia and anxiety The brand name Compazine is discontinued in the U.S. Patients in the high-risk group were to take 4 mg phenergan vs ondansetron dose of dexamethasone twice daily or the combination of 8 mg of ondansetron and 4 mg of dexamethasone twice daily. Replacement of Phenergan (promethazine) with Zofran (ondansetron) for Treatment of Opioid and Trauma-Related Nausea and Vomiting in Tactical Combat Casualty Care TCCC Guidelines - Change 14-03 3 April 2015 LCDR Dana J. If you are worried about getting sleepy (I would be worried as well), I would suggest starting a fiber regimen as soon as you start the Zofran - hopefully this will prevent you from ever getting constipated in the first place Promethazine (Phenergan) 12.5 to 25 mg orally every four to six hours. C. What do I take? al. Other drugs that have the same active ingredients (e.g. A block-balanced randomization list. If that does not work, then you probably need a prescription for Zofran which blocks the nausea and vomiting (which is caused by the drugs) Examples of DOC - Promethazine; Type of Nausea - T oxins stimulating the CTZ in the brain such as Opioids*** Receptors Causing Nausea - Dopamine 2, 5HT3 Drug Class Useful - Antidopaminergic, 5HT3 Antagonist Examples of DOC - Prochlorperazine, Haloperidol, Ondansetron * The most common cause of bowel obstruction is constipation..Ondansetron rated 7.9/10 vs Phenergan rated 7.8/10 in overall patient satisfaction Ondansetron is an anti-nausea medication used to prevent nausea and vomiting caused by cancer chemotherapy.It is also used to prevent vomiting and nausea after surgery.